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Can commercial supporters distribute promotional materials for CME activities, like "save the date announcements and brochures?"

Yes. Distributing promotional materials for accredited education such as save the date announcements and brochures, is not prohibited by the ACCME's Standards for Integrity and Independence.  

Note that Standard 5.3 prohibits ineligible companies from providing access to (such as a link), or distributing, the accredited education itself to learners. 

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